| Citation | Bersin, T.V., Cordova, K.L., Journey, M.L., Beckman, B.R., and Lema, S.C. 2023. Food deprivation reduces sensitivity of liver Igf1 synthesis pathways to GH stimulation in juvenile gopher rockfish (Sebastes carnatus). Gen Comp. Endocrinol. 346:114404 (https://doi.org/10.1016/j.ygcen.2023.114404 Get rights and content) |
| Title | Food deprivation reduces sensitivity of liver Igf1 synthesis pathways to growth hormone in juvenile gopher rockfish (Sebastes carnatus) |
| Publication Year | 2024 |
| Volume | 346 |
| Pages | 114404 |
| Keywords | growth, rockfish |
| Abstract | Growth hormone (Gh) regulates growth in part by stimulating the liver to synthesize and release insulin-like growth factor-1 (Igf1), which then promotes somatic growth. However, for fish experiencing food limitation, elevated blood Gh can occur even with low circulating Igf1 and slow growth, suggesting that nutritional stress can alter the sensitivity of liver Igf1 synthesis pathways to Gh. Here, we examined how recent feeding experience affected Gh regulation of liver Igf1 synthesis pathways in juvenile gopher rockfish (Sebastes carnatus) to test how igf1 gene expression responds to Gh in rockfish under differing feeding conditions and illuminate mechanisms underlying the nutritional modulation of Igf1 production. Juvenile gopher rockfish were maintained under conditions of feeding or complete food deprivation (fasting) for 14 d and then treated with recombinant sea bream (Sparus aurata) Gh or saline control. Gh upregulated hepatic igf1 mRNA levels in fed fish but not in fasted fish. |
| Official Citation | Bersin, T.V., Cordova, K.L., Journey, M.L., Beckman, B.R., and Lema, S.C. 2023. Food deprivation reduces sensitivity of liver Igf1 synthesis pathways to GH stimulation in juvenile gopher rockfish (Sebastes carnatus). Gen Comp. Endocrinol. 346:114404 |
| Links | (https://doi.org/10.1016/j.ygcen.2023.114404 Get rights and content) |