| Citation | Bersin, T.V., Cordova, K.L., Saenger, E.K., Journey, M.L., Beckman, B.R., and Lema, S.C. 2023. Nutritional status affects Igf1 regulation of skeletal muscle myogenesis, myostatin, and myofibrillar protein degradation pathways in gopher rockfish (Sebastes carnatus). Mol. Cell. Endocrinol. 573: 111951 (https://doi.org/10.1016/j.mce.2023.111951) |
| Title | Nutritional status affects Igf1 regulation of skeletal muscle myogenesis, myostatin, and myofibrillar protein degradation pathways in gopher rockfish (Sebastes carnatus) |
| Publication Year | 2024 |
| Volume | 573 |
| Pages | 111951 |
| Keywords | growth, rockfish, igf1 |
| Abstract | Insulin-like growth factor-1 (Igf1) regulates skeletal muscle growth in fishes by increasing protein synthesis and promoting muscle hypertrophy. When fish experience periods of insufficient food intake, they undergo slower muscle growth or even muscle wasting, and those changes emerge in part from nutritional modulation of Igf1 signaling. Here, we examined how food deprivation (fasting) modulates Igf1 regulation of liver and skeletal muscle gene expression in gopher rockfish (Sebastes carnatus), a nearshore rockfish of importance for commercial and recreational fisheries in the northeastern Pacific Ocean, to understanding how food limitation impacts Igf regulation of muscle growth pathways. Rockfish were either fed or fasted for 14 d, after which a subset of fish from each group was treated with recombinant Igf1 from sea bream (Sparus aurata). Fish that were fasted lost body mass and had lower body condition, reduced hepatosomatic index, and lower plasma Igf1 concentrations, as well as |
| Official Citation | Bersin, T.V., Cordova, K.L., Saenger, E.K., Journey, M.L., Beckman, B.R., and Lema, S.C. 2023. Nutritional status affects Igf1 regulation of skeletal muscle myogenesis, myostatin, and myofibrillar protein degradation pathways in gopher rockfish (Sebastes carnatus). Mol. Cell. Endocrinol. 573: 111951 |
| Links | (https://doi.org/10.1016/j.mce.2023.111951) |